Chicago (37-22-10) lost 4-3 in overtime at Columbus on Wednesday to fall to 3-7-2 since winning four in a row.
"Obviously, the way we've been playing, it's good to get a point," said Chicago's Patrick Kane, who had a goal with an assist against the Blue Jackets. "But you want to go in and win that game. So it's disappointing not to get two."
An extra point could have helped Chicago, which fell out of fourth place - the last spot that carries home-ice advantage in the first round - in the Western Conference after Vancouver beat St. Louis 3-0 on Thursday to move ahead of the Blackhawks by one point.
Facing Edmonton (34-27-9) could give the Blackhawks some confidence heading into this contest.
Though the Oilers are seventh in the West, they've been outscored 15-3 in losing the previous three games to the Blackhawks. Chicago hasn't swept a series from the Oilers since 1994-95.
Kane has a goal and three assists against Edmonton this season.